Two years after the incident on Mars, research has resumed, led by Dr. Elizabeth McNeil. Once more, strange occurrences haunt the facility. A search team breaks into a chamber deep within Mars, finding the Artifact — a weapon from Hell that the Ancients sealed away long ago.
The lead Marine, upon touching the Artifact, awakens it, the blast wave killing his team and reaching into Hell, alerting the Maledict (Dr. Betruger’s new form). The Maledict sends the three Hunters to retrieve the Artifact. Meanwhile, Hell begins to invade Mars once again.